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REFLECTIONS
Hypertension
Hypertension Global Newsletter #5 2023
Hypertension
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FOR AN INTERESTING COMMENTARY
ARTICLE BY MAGNANI JW
REFLECTING ON THE NEED
FOR SOCIAL SOLUTIONS FOR
HYPERTENSION.
TREATMENT
Systolic blood pressure time in target range and cognitive outcomes: Insights
from the SPRINT MIND Trial.
Li S, et al. Hypertension. 2023 Aug;80(8):1628-1636.
In this post-hoc analysis of the Systolic Blood Pressure is calculated as the proportion of time that SBP is within a
Intervention Trial Memory and Cognition in Decreased specified range. Previous studies have found that in patients
Hypertension (SPRINT MIND) trial, the authors aimed to with hypertension, higher time in the SBP target range was
evaluate the prognostic value of SBP time in target range associated with a lower risk of all-cause mortality.
(TTR) on cognitive outcomes among adults with hypertension
(n=8298). In this study, TTR was calculated from baseline to Month
3 using 110 to 130 mmHg for the intensive group, and 120
A single BP value or mean BP may not fully reflect the clinical to 140 mmHg as the target range for the control (standard
performance of BP control. Since BP levels can fluctuate treatment) group. For sensitivity analysis, the authors also
over time, TTR is a novel metric of BP management and analyzed the data when the SBP target range was 110 to 140
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